In their clinical trials, the Pfizer and Moderna vaccines did okay , well enough for the FDA to grant emergency use authorization. But in a real-world study, where participants were all on the front lines fighting Covid, the vaccines demonstrated 90% effective against the virus – not just the symptomatic disease. In the clinical studies , Pfizer and Moderna were testing against disease .
According to the CDC-sponsored research published today, it didn’ t matter which vaccine the participants received . What mattered was that both sexes were created using messenger RNA to repel the coronavirus. The results showed that the vaccines were even effective against asymptomatic virus.
Messenger RNA, or mRNA, carries instructions into a mobile to tell it how to function . In the event of the vaccines, the goal for the message is that the spike protein. This protein contains three functions : it acknowledges the virus, it permits the virus to attach to it, and then it allows entry into the cell. Once that happens , all viral hell breaks loose. But with all the vaccines, the messenger is relaying instructions to create antigens, those molecules that tell the immune system to recognize an invading force. This allows the body to recognize and attack the spike protein on actual SARS-CoV-2 viruses if a person comes in contact with them.
And seemingly , recognize it they do.
The CDC wanted to understand how the mRNA vaccines worked in the real world , so they enrolled 3,950 people – healthcare workers, first responders, and others – from six states. The 13-week study ran from mid-December to mid-March.
The vaccines did well even with just 1 shot, although the two types typically require two shots for a complete regimen. In the study , the risk of infection dropped by 80%, fourteen days after the initial dose of vaccine was given.
The participants submitted their own nasal swabs every week for testing. Close to 11% of the infections contracted were asymptomatic. Nearly 60 percent of these infections were discovered before the infected person developed symptoms. In total, 205 people had diagnosed infections. It is worth noting that 69% of those in the study did not have any chronic problems . About 1,200 had more than one.
Slimming down where the infections occurred, the study said those infected were largely male, Hispanic, first responders. The states with the most cases were Texas, Florida and Arizona.
“The analysis shows that these two mRNA vaccines can reduce the chance of all SARS-CoV-2 infections, not just symptomatic infections,” a CDC press release said.